Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lanzi, G.
Right arrow Articles by Lebon, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lanzi, G.
Right arrow Articles by Lebon, P.
Related Collections
Right arrow Developmental disorders
Right arrow All Epilepsy/Seizures
NEUROLOGY 2005;64:1621-1624
© 2005 American Academy of Neurology
Brief Communications

The natural history of Aicardi–Goutières syndrome: Follow-up of 11 Italian patients

G. Lanzi, MD, E. Fazzi, MD, S. D’Arrigo, MD, S. Orcesi, MD, I. Maraucci, MD, C. Uggetti, MD, E. Bertini, MD and P. Lebon, MD

From the Departments of Child Neurology and Psychiatry (Drs. Lanzi, Fazzi, D’Arrigo, Orcesi, Maraucci) and Neuroradiology (Dr. Uggetti), IRCCS "C. Mondino Institute of Neurology," University of Pavia, and Department of Laboratories (Dr. Bertini), Unit of Molecular Medicine, Bambino Gesù Children’s Research Hospital, Rome, Italy; and Department of Infectious Diseases and Virology (Dr. Lebon), St. Vincent de Paul Hôpital, René Descartes University, Paris, France.

Address correspondence and reprint requests to Dr. G. Lanzi, Department of Child Neurology and Psychiatry, IRCCS "C. Mondino Institute of Neurology," University of Pavia, Via Mondino 2, 27100 Pavia, Italy; e-mail: glanzi{at}unipv.it

Described are the outcomes of 11 Italian patients with Aicardi–Goutières syndrome. Neurologic symptoms progressed in the first year of life and stabilized by the end of the second year in 10 patients. White matter abnormalities remained stable; cerebral atrophy was stable in four patients and progressive in two. Calcifications increased (in number and size) in two of six patients. Serial CSF and serum interferon-{alpha} measurements (three patients) showed reduced CSF interferon-{alpha} levels.

Supported by a grant from the "Fondazione Cariplo," Italy.

Received May 27, 2004. Accepted in final form January 17, 2005.




This article has been cited by other articles:


Home page
 Br Med BullHome page
S. Orcesi, R. La Piana, and E. Fazzi
Aicardi-Goutieres syndrome
Br. Med. Bull., March 1, 2009; 89(1): 183 - 201.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.