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NEUROLOGY 2005;64:1632-1634
© 2005 American Academy of Neurology
Brief Communications

Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy

G. Lopate, MD, A. Pestronk, MD, S. Evans, PhD, L. Li, BS and D. Clifford, MD

From the Department of Neurology (Drs. Lopate Pestronk, and Clifford), Washington University, St. Louis, MO; and Department of Biostatistics (Dr. Evans and L. Li), Harvard University, Boston, MA.

Address correspondence and reprint requests to Dr. Glenn Lopate, Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110; e-mail: lopateg{at}neuro.wustl.edu

We used ELISA to estimate the prevalence of anti-sulfatide antibodies in HIV-infected individuals with distal sensory neuropathy (DSP) and compared the results with the prevalence in HIV-infected individuals without DSP and in individuals with neuropathy who are not infected with HIV. We found that 36% of HIV+/DSP+ individuals had immunoglobulin (Ig) G anti-sulfatide antibody titers greater than 1,500, whereas IgG anti-sulfatide antibodies were rarely found in HIV+/DSP– or HIV–/DSP+ patients.

Dr. Evans was supported by the NIH Statistical and Data Management Center grant number 5 U01 AI038855-08 and the Neurologic AIDS Research Consortium grant 2 U01 NS0322228-08A1. Dr. Clifford was supported by grants NS322228, AI25903, and NIMH-22005. ACTG 291 (Dr. Justin McArthur, PI), which contributed specimens to analysis was funded by the ACTG (AI38858) and by the Neurologic AIDS Research Consortium (NS32228). Drs. Lopate and Pestronk were supported by a grant from the Washington University Neuromuscular Research Fund.

Received August 19 2004. Accepted in final form January 21, 2005.




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