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Effects of chronic lead exposure on ¹H MRS of hippocampus and frontal lobes in children

From the School of Life Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.

Address correspondence and reprint requests to Dr. Di-Yun Ruan, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China; e-mail: Ruandy{at}ustc.edu.cn

The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. The reductions were right frontal > left frontal > hippocampus but were the same bilaterally in the hippocampus.

Supported by the National Basic Research Program of China (No. 2002CB512907), Academic Sinica (No. KZCX3-SW-437), the National Nature Science Foundation of China (No. 30170809, 30000039,30300288), Specialized Research Fund for the Doctoral Program of Higher Education (No. 20020358053), and the University of Science and Technology of China (No. KB0833, BH0813).

Received March 5, 2004. Accepted in final form January 25, 2005.

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				J. P. Wright, D. Boisvert, and J. Vaske Blood Lead Levels in Early Childhood Predict Adulthood Psychopathy Youth Violence and Juvenile Justice, July 1, 2009; 7(3): 208 - 222. [Abstract] [PDF]

				D. Mandelbaum, D.-Y. Ruan, X.-M. Meng, D.-M. Zhu, J.-Q. Zhu, and L. Luo Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children Neurology, February 28, 2006; 66(4): 614 - 614. [Full Text] [PDF]

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