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NEUROLOGY 2005;64:1651-1654
© 2005 American Academy of Neurology
Brief Communications

Identification of candidates for epilepsy surgery in patients with tuberous sclerosis

D. K. Lachhwani, MBBS, MD, E. Pestana, MD, A. Gupta, MD, P. Kotagal, MD, W. Bingaman, MD and E. Wyllie, MD

From the Departments of Neurology (Drs. Lachhwani, Pestana, Gupta, Kotagal, and Wyllie) and Neurosurgery (Dr. Bingaman), The Cleveland Clinic Foundation, OH.

Address correspondence and reprint requests to Dr. Deepak K. Lachhwani, Section of Pediatric Epilepsy and Pediatric Neurology, The Cleveland Clinic Foundation, 9500 Euclid Ave, S-51, Cleveland, OH 44195; e-mail: lachhwd{at}ccf.org

The authors reviewed preoperative MRI and EEG findings in relation to postsurgical outcome in 17 patients with refractory epilepsy due to tuberous sclerosis complex (TSC). Resecting concordant MRI (main tuber) and EEG abnormalities offered seizure freedom (8/9, 89%; median follow-up 25 months) comparable to other focal etiologies. Patients with nonconcordant MRI and EEG findings did less well (3/8, 38%, seizure free; p = 0.027, OR = 13).

Received May 18, 2004. Accepted in final form January 26, 2005.




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