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Epileptiform EEG abnormalities in children with language regression

From the Departments of Neurology, Pediatrics, and the Comprehensive Epilepsy Management Center, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY.

Address correspondence and reprint requests to Dr. Kathryn A. McVicar, Epilepsy Management Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467; e-mail: kmcvicar1{at}optonline.net

The authors examined the records of 149 children with language regression (LR) who had overnight EEG monitoring. Children with isolated LR had a higher frequency of epileptiform abnormalities (60%) than those with LR in the context of autistic regression (31%, p = 0.002) and also a higher rate of clinical seizures (33% vs 8%, p < 0.001). EEG abnormalities in the LR only group were also more prominent. This suggests two subtypes of language regression.

Editorial, see page 11

Supported in part by NIH grants K12 NS048856 from NINDS and RR-17672, Epilepsy Foundation-Gower’s Fellowship Training Grant (Dr. McVicar) from the NINDS and the Cure Autism Now (CAN) foundation (Dr. Rapin).

Presented in part at the American Epilepsy Society Meetings, Boston, MA, December 2003.

Received December 10, 2004. Accepted in final form March 22, 2005.

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