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NEUROLOGY 2005;65:147-149
© 2005 American Academy of Neurology
Brief Communications

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury

C. R. Baumann, MD, R. Stocker, MD, H. -G. Imhof, MD, O. Trentz, MD, M. Hersberger, MD, E. Mignot, MD, PhD and C. L. Bassetti, MD

From the Departments of Neurology (Drs. Baumann and Bassetti), Intensive Care Medicine (Dr. Stocker), Neurosurgery (Dr. Imhof), and Traumatic Surgery (Dr. Trentz), Institute of Clinical Chemistry (Dr. Hersberger), University Hospital, Zürich, Switzerland; and Stanford Center for Narcolepsy (Dr. Mignot), Palo Alto, CA.

Address correspondence and reprint requests to Dr. Claudio L. Bassetti, Department of Neurology, Universitätsspital Zürich Frauenklinikstrasse 26, 8091 Zürich, Switzerland; e-mail: claudio.bassetti{at}usz.ch

Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.

Received July 7, 2004. Accepted in final form April 6, 2005.




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