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Published online before print June 15, 2005, doi:10.1212/01.WNL.0000167129.90918.f5)
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NEUROLOGY 2005;65:153-155
© 2005 American Academy of Neurology
Brief Communications

High sensitivity measurement of CRP and disease progression in multiple sclerosis

M. Soilu-Hänninen, MD, PhD, J. O. Koskinen, MSc, M. Laaksonen, MD, A. Hänninen, MD, PhD, E. -M. Lilius, PhD and M. Waris, PhD

From the Departments of Neurology (Dr. Soilu-Hänninen), Virology (Dr. Laaksonen), Biochemistry (Dr. Lilius), and Medical Microbiology (Dr. Hänninen), and the Laboratory of Biophysics (Dr. Koskinen), Institute of Biomedicine, University of Turku, Finland.

Address correspondence and reprint requests to Dr. Merja Soilu-Hänninen, Department of Neurology, University of Turku, Kiinamyllynkatu 4-8, PL 52, FIN-20521 Turku, Finland; e-mail: mersoi{at}utu.fi

The authors measured serum C-reactive protein (CRP) serially in patients with multiple sclerosis (MS) who participated the PRISMS study using a high-sensitivity technique. CRP values were similar in patients with MS and in healthy controls but higher during MS relapses than in remission (p = 0.010). CRP levels were lower during treatment with high-dose interferon beta 1a than placebo (p = 0.035) and higher during first 12 months of study in patients who progressed by year 4 compared with stable patients (p = 0.007).

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 12 issue to find the title link for this article.

Supported by the Finnish Medical Foundation Duodecim and the Finnish Foundation of Neurology (MS-H) and the Finnish Diabetes Research Foundation (AH).

Received February 15, 2005. Accepted in final form April 6, 2005.




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