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NEUROLOGY 2005;65:1643-1645
© 2005 American Academy of Neurology
Brief Communications

Lack of association between VEGF polymorphisms and ALS in a Dutch population

P.W.J. Van Vught, MSc, N. A. Sutedja, MD, J. H. Veldink, MD, PhD, B. P.C. Koeleman, PhD, G. J. Groeneveld, MD, PhD, C. Wijmenga, PhD, B. M.J. Uitdehaag, MD, PhD, J. M.B.V. de Jong, MD, PhD, F. Baas, PhD, J. H.J. Wokke, MD, PhD and L. H. Van den Berg, MD, PhD

From the Departments of Neurology (Drs. Van Vught, Sutedja, Veldink, Groeneveld, Wokke, and Van den Berg) and Medical Genetics (Drs. Koeleman and Wijmenga), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht; Department of Neurology (Dr. Uitdehaag), VU University Medical Center, Amsterdam; and Departments of Neurogenetics (Dr. Baas) and Neurology (Dr. De Jong), Academic Medical Center, University of Amsterdam, The Netherlands.

Address correspondence and reprint requests to P.W.J. Van Vught, Department of Neurology, G02.320, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; e-mail: p.w.j.vanvught{at}neuro.azu.nl

Sequence alterations in the promoter region of the vascular endothelial growth factor (VEGF) gene have been implicated in increasing the risk of developing ALS. VEGF promoter haplotypes were determined in 373 patients with sporadic ALS and 615 matched healthy controls in The Netherlands. No significant association between the previously reported at-risk haplotypes and ALS was found. Pooling our results with the previously studied population still showed a significant association with the AAG haplotype.

Supported by a grant from the Netherlands Organization for Health Research and Development.

Disclosure: The authors report no conflicts of interest.

Received March 29, 2005. Accepted in final form August 8, 2005.




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