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NEUROLOGY 2005;65:1654-1656
© 2005 American Academy of Neurology
Brief Communications

Benefits of rivastigmine on attention in dementia associated with Parkinson disease

K. A. Wesnes, PhD, I. McKeith, MD, C. Edgar, MSc, M. Emre, MD and R. Lane, MD

From Cognitive Drug Research (Dr. Wesnes and C. Edgar), Goring-on-Thames, United Kingdom; Newcastle General Hospital (Dr. McKeith), Newcastle-upon-Tyne, United Kingdom; the Istanbul Faculty of Medicine (Dr. Emre), Istanbul, Turkey; and Novartis Pharmaceuticals (Dr. Lane), East Hanover, NJ.

Address correspondence and reprint requests to Dr. Keith A. Wesnes, Cognitive Drug Research Ltd., CDR House, Gatehampton Road, Goring-on-Thames, RG8 0EN, UK; e-mail: keithw{at}cdr.org.uk

In a 24-week, randomized, double-blind, placebo-controlled, multicenter study of rivastigmine, 487 patients with dementia associated with Parkinson disease underwent assessment of attention on the Cognitive Drug Research computerized cognitive assessment system before dosing and 16 and 24 weeks later. Significant benefits of rivastigmine over placebo were seen on all aspects of attention assessed: sustained attention, focused attention, consistence of responding, and central processing speed.

Supported by Novartis Pharma AG.

Disclosure: K.A. Wesnes, PhD, is the owner of Cognitive Drug Research Ltd., which was financially supported in excess of $10,000 for its involvement in this study. C. Edgar, MSc, is a nonequity employee of Cognitive Drug Research Ltd. I. McKeith, MD, has received honoraria from Novartis. M. Emre, MD, has received study grants (in excess of $10,000) and honoraria from Novartis. R. Lane, MD, is an employee of Novartis and owns stock options in excess of $10,000.

Received April 27, 2005. Accepted in final form August 5, 2005.


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