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From the Davee Department of Neurology and Neurological Sciences (Drs. Videnovic, Semenov, Chua-Adajar, Simuni, Raizer), Department of Radiology, Section of Neuroradiology (Dr. Futterer), Northwestern University, Feinberg School of Medicine; Department of Medicine (Drs. Baddi, Gradishar, Tellez), Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL; Departments of Neurology, Neurosurgery and Medicine, Division of Oncology, Huntsman Cancer Institute (Dr. Blumenthal) and Utah Cancer Specialists, Department of Medicine (Dr. Beck), University of Utah, Salt Lake City.
Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.
Commentary, see page 1685
This article was previously published in electronic format as an Expedited E-Pub on October 19, 2005, at www.neurology.org.
Disclosure: The authors report no conflicts of interest.
Received June 15, 2005. Accepted in final form September 13, 2005.
Address correspondence and requests reprints to Dr. Jeffrey J. Raizer, Davee Department of Neurology and Neurological Sciences, Northwestern University, Feinberg School of Medicine, 710 North Lake Shore Drive, Abbott Hall, Room 1123, Chicago, IL 60611; e-mail: Jraizer{at}nmff.org
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