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Published online before print October 19, 2005, doi:10.1212/01.wnl.0000187313.83515.7e)
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Volume 65, Number 11, December 13, 2005
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NEUROLOGY 2005;65:1792-1794
© 2005 American Academy of Neurology


Brief Communications

Capecitabine-induced multifocal leukoencephalopathy: A report of five cases

A. Videnovic, MD, I. Semenov, MD, R. Chua-Adajar, MD, L. Baddi, MD, D. T. Blumenthal, MD, A. C. Beck, MD, T. Simuni, MD, S. Futterer, MD, W. Gradishar, MD, C. Tellez, MD and J. J. Raizer, MD

From the Davee Department of Neurology and Neurological Sciences (Drs. Videnovic, Semenov, Chua-Adajar, Simuni, Raizer), Department of Radiology, Section of Neuroradiology (Dr. Futterer), Northwestern University, Feinberg School of Medicine; Department of Medicine (Drs. Baddi, Gradishar, Tellez), Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL; Departments of Neurology, Neurosurgery and Medicine, Division of Oncology, Huntsman Cancer Institute (Dr. Blumenthal) and Utah Cancer Specialists, Department of Medicine (Dr. Beck), University of Utah, Salt Lake City.

Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.


Commentary, see page 1685

This article was previously published in electronic format as an Expedited E-Pub on October 19, 2005, at www.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received June 15, 2005. Accepted in final form September 13, 2005.

Address correspondence and requests reprints to Dr. Jeffrey J. Raizer, Davee Department of Neurology and Neurological Sciences, Northwestern University, Feinberg School of Medicine, 710 North Lake Shore Drive, Abbott Hall, Room 1123, Chicago, IL 60611; e-mail: Jraizer{at}nmff.org




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