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Published online before print October 12, 2005, doi:10.1212/01.wnl.0000183702.04080.27)
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 Volume 65, Number 11, December 13, 2005
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NEUROLOGY 2005;65:1795-1798
© 2005 American Academy of Neurology
Brief Communications

Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis

S. T. Engelter, MD, M. Reichhart, MD, L. Sekoranja, MD, D. Georgiadis, MD, A. Baumann, MD, B. Weder, MD, F. Müller, MD, R. Lüthy, MD, M. Arnold, MD, P. Michel, MD, H. P. Mattle, MD, B. Tettenborn, MD, H. J. Hungerbühler, MD, R. W. Baumgartner, MD, R. Sztajzel, MD, J. Bogousslavsky, MD and P. A. Lyrer, MD

From the Stroke Units and Neurological Clinics/Departments of Neurology, University Hospital Basel (Drs. Engelter and Lyrer), University Hospital Lausanne (Drs. Reichhart, Michel, and Bogousslavsky), University Hospital Bern (Drs. Arnold and Mattle), University Hospital Geneva (Drs. Sekoranja and Sztajzel), University Hospital Zurich (Drs. Georgiadis and Baumgartner), Cantonal Hospital Aarau (Drs. Baumann and Hungerbühler), Cantonal Hospital St. Gallen (Drs. Weder and Tettenborn), Cantonal Hospital Thurgau Muensterlingen (Dr. Müller), and Department of Internal Medicine, Triemli Hospital Zurich (Dr. Lüthy), Switzerland.

Address correspondence and reprint requests to Dr Engelter, Neurological Clinic and Stroke Unit, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; e-mail: sengelter{at}uhbs.ch

This databank-based, multicenter study compared all stroke patients with IV tissue plasminogen activator aged ≥80 years (n = 38) and those <80 years old (n = 287). Three-month mortality was higher in older patients. Favorable outcome (modified Rankin scale ≤1) and intracranial hemorrhage (asymptomatic/symptomatic/fatal) were similarly frequent in both groups. Logistic regression showed that stroke severity, time to thrombolysis, glucose level, and history of coronary heart disease independently predicted outcome, whereas age did not.

Editorial, see page 1690

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 13 issue to find the title link for this article.

This article was previously published in electronic format as an Expedited E-Pub on October 12, 2005, at www.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received March 18, 2005. Accepted in final form August 17, 2005.




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