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Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid

From the Department of Medicine, Section of Pediatrics, University of Chieti (Drs. Greco, Chiarelli, and Verrotti); Division of Neonatology, Perrino Hospital, Brindisi; Clinical Physiology Institute, National Council of Italy, IFC-CNR-CREAS, Lecce Section (Dr. Latini); and Department of Pediatrics, University of Rome, Italy (Dr. Iannetti).

Address correspondence and reprint requests to Dr. Alberto Verrotti, Department of Pediatrics, University of Chieti Ospedale Policlinico, Via dei Vestini 5, 66013 Chieti, Italy; e-mail: averrott{at}unich.it

The authors studied 40 epileptic patients treated with valproate and 40 healthy controls for at least 2 years. At the end of follow-up, 15 epileptic patients (37.5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight.

Disclosure: The authors report no conflicts of interest.

Received June 24, 2005. Accepted in final form August 25, 2005.

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