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Low-glycemic-index treatment: A liberalized ketogenic diet for treatment of intractable epilepsy

From the Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. Elizabeth A. Thiele, Pediatric Epilepsy Service, Massachusetts General Hospital, 175 Cambridge St., Suite 340, Boston, MA 02114; e-mail: ethiele{at}partners.org

The ketogenic diet is often effective for intractable epilepsy, but many patients have trouble complying with the strict regimen. The authors tested an alternative diet regimen, a low-glycemic-index treatment, with more liberal total carbohydrate intake but restricted to foods that produce relatively little increase in blood glucose (glycemic index < 50). Ten of 20 patients treated with this regimen experienced a greater than 90% reduction in seizure frequency.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 13 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received February 17, 2005. Accepted in final form August 17, 2005.

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