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From the Memory and Aging Center (J.S. Goldman, Drs. Johnson, Boxer, and Miller), University of California, San Francisco; Center for Neurodegenerative Disease Research (J.M. Farmer, B.M. Wood, Dr. Lee), University of Pennsylvania, Philadelphia; Departments of Genetics and Neurology (Dr. Wilhelmsen), University of North Carolina, Chapel Hill; ALS Center (Dr. Lomen-Hoerth), University of California, San Francisco; Department of Neurology (Dr. Grossman), Hospital of the University of Pennsylvania, Philadelphia; Department of Epidemiology and Biostatistics (Dr. Neuhaus), University of California, San Francisco.
Address correspondence and reprint requests to J.S. Goldman, UCSF Memory and Aging Center, 350 Parnassus Avenue, Suite 706, San Francisco, CA 94117; e-mail: jgoldman{at}memory.ucsf.edu
Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.
Funding was provided by National Institute on Aging grants P01-AG19724, P50-AG16753, AG10123, and AG17586; California Department of Health Services grants 03-75271, 01-15945, and 04-35514; and National Center for Research Resources, U.S. Public Health Service grant 5 M01 RR-00079.
Disclosure: The authors report no conflicts of interest..
Received May 11, 2005. Accepted in final form August 17, 2005.
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