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NEUROLOGY 2005;65:1958-1960
© 2005 American Academy of Neurology
Brief Communications

Elevated IL-6 and TNF-{alpha} levels in patients with ALS: Inflammation or hypoxia?

C. Moreau, MD, D. Devos, MD, PhD, V. Brunaud-Danel, MD, L. Defebvre, MD, PhD, T. Perez, MD, A. Destée, MD, A. B. Tonnel, MD, PhD, P. Lassalle, MD, PhD and N. Just, MD

From the Department of Neurology (Drs. Moreau, Devos, Brunaud-Danel, Defebvre, and Destée), Department of Pneumology (Drs. Perez Tonnel, and Just), and U 416 (Drs. Tonnel, Lassalle, and Just), INSERM, Pasteur Institute of Lille, University Hospital, Lille, France.

Address correspondence and reprint requests to Dr. David Devos, Clinique Neurologique, Hôpital R. Salengro, CHU, F-59037 Lille Cedex, France; e-mail: d-devos{at}chru-lille.fr

Abnormal levels of interleukin (IL)-6 were described in patients with ALS, related to an inflammatory process. The authors compared IL-6 and tumor necrosis factor {alpha} (TNF-{alpha}) levels in CSF and sera from 10 hypoxemics and 10 normoxemics patients with ALS to those of 10 hypoxemics and 10 normoxemics neurologic controls. The same pattern exists in patients with ALS and controls: the highest levels are found in hypoxic conditions and undetectable levels are found in normoxemic conditions. Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia.

Supported by grants from the Association pour la Recherche sur la SLA (ARS).

Disclosure: The authors report no conflicts of interest.

Received June 20, 2005. Accepted in final form August 30, 2005.




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