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 Volume 65, Number 12, December 27, 2005
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NEUROLOGY 2005;65:1976-1978
© 2005 American Academy of Neurology
Brief Communications

Hyponatremia from oxcarbazepine and carbamazepine

Xiaoming Dong, MD, Ilo E. Leppik, MD, James White, MD and John Rarick

From the Departments of Neurology (Drs. Dong, Leppik, and White) and College of Pharmacy (Drs. Leppik and Rarick), University of Minnesota; and MINCEP Epilepsy Care (Drs. Leppik and White), Minneapolis, MN.

Address correspondence and reprint requests to Dr. Xiaoming Dong, Department of Neurology, University of Minnesota, 12-100 PWB (MMC295), 420 Delaware Street SE, Minneapolis, MN 55455; e-mail: dongx015{at}umn.edu

The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ <<134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ <<128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.

Disclosure: The authors report no conflicts of interest.

Received August 1, 2004. Accepted in final form July 19, 2005.




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