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The smoking–thrombolysis paradox and acute ischemic stroke

From the Stroke Center and Department of Neurology, UCLA Medical Center, and Department of Neurology, Olive View–UCLA Medical Center, Los Angeles, CA.

Address correspondence and reprint requests to Dr. B. Ovbiagele, Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095; e-mail: Ovibes{at}mednet.ucla.edu

Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.

See Commentary, page 183

This article was previously published in electronic format as an Expedited E-Pub on June 15, 2005, at www.neurology.org.

Supported in part by NIH-NINDS award P50 NS044378 (JLS).

Received December 3, 2004. Accepted in final form April 13, 2004.

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