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Association of the metabolic syndrome with intracranial atherosclerotic stroke

From the Department of Neurology, School of Medicine, Ajou University, Suwon, South Korea.

Address correspondence and reprint requests to Dr. Oh Young Bang, Department of Neurology, School of Medicine, Ajou University, Woncheon-dong San 5, Paldal-ku, Suwon, Kyungki-do, 442-749, South Korea; e-mail: nmboy{at}unitel.co.kr

To investigate the impact of metabolic syndrome (MetSD) on the development of intracranial atherosclerotic stroke, the authors evaluated the components of the MetSD in 512 patients with stroke. The MetSD was observed most frequently in patients with intracranial atherosclerosis (p = 0.007). In multiple regression analysis, the MetSD, but not conventional risk factors, was independently associated with intracranial atherosclerosis (p = 0.005). The results suggest that treatment of metabolic abnormalities may be an important prevention strategy for intracranial atherosclerosis.

Editorial, see page 188

Supported by Korea Research Foundation grant KRF-2003-E00228.

Received November 4, 2004. Accepted in final form March 30, 2005.

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