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 Volume 65, Number 2, July 26, 2005
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NEUROLOGY 2005;65:302-304
© 2005 American Academy of Neurology
Brief Communications

Acute painful neuropathy in thallium poisoning

H. -C. Kuo, MD, C. -C. Huang, MD, Y. -T. Tsai, MD, C. -C. Chu, MD, S. -T. Hsieh, MD, PhD and N. -S. Chu, MD, PhD

From the Department of Neurology (Drs. Kuo, Huang, Tsai, C.-C. Chu, and N.-S. Chu), Chang Gung Memorial Hospital and University; and Department of Anatomy and Cellular Biology (Dr. Hsieh), College of Medicine, National Taiwan University, Taipei.

Address correspondence and reprint requests to Dr. Chin-Chang Huang, Department of Neurology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan; e-mail: cch0537{at}adm.cgmh.org.tw

Dysesthesia, allodynia, distal muscle weakness, and sensory impairment were noted in two patients with acute thallium intoxication. Two months later, nerve conduction studies showed an axonal degeneration. Sural nerve biopsy disclosed a decreased fiber density in the large myelinated fibers. Quantitative sensory testing also revealed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy confirmed a loss of epidermal nerves indicating an involvement of the small sensory nerves.

Supported in part by a grant from the National Science Council (NSC 92-2314-B-182A-117).

Received December 30, 2004. Accepted in final form March 29, 2005.




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