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NEUROLOGY 2005;65:311-313
© 2005 American Academy of Neurology
Brief Communications

Mechanical hyperalgesia in complex regional pain syndrome: A role for TNF-{alpha}?

Christian Maihöfner, MD, PhD, Hermann O. Handwerker, MD, PhD, Bernhard Neundörfer, MD, PhD and Frank Birklein, MD, PhD

From the Departments of Neurology (Drs. Maihöfner and Neundörfer) and Physiology and Experimental Pathophysiology (Drs. Maihöfner and Handwerker), University of Erlangen-Nuremberg, Erlangen, Germany; and Department of Neurology (Dr. Birklein), University of Mainz, Mainz, Germany.

Plasma concentrations of soluble tumor necrosis factor {alpha} (TNF-{alpha}) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 ± 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 ± 56.3 pg/mL) and controls (1,239.5 ± 42.9 pg/mL). This study suggests involvement of TNF-{alpha} in mechanical hyperalgesia of CRPS.

Supported by the German Research Network Neuropathic Pain Syndromes (German Federal Ministry of Education and Research, BMBF) and the German Research Foundation (Bi 579/1).

Received November 4, 2004. Accepted in final form April 7, 2005.

Address correspondence and reprint request to Dr. Christian Maihöfner, Institute for Physiology and Experimental Pathophysiology, University of Erlangen-Nuremberg, Universitätsstrasse 17, D-91054 Erlangen, Germany; e-mail: maihoefner{at}physiologie1.uni-erlangen.de




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