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NEUROLOGY 2005;65:314-316
© 2005 American Academy of Neurology
Brief Communications

Clinical features of status epilepticus in patients with HIV infection

Kelly C. Lee, PharmD, BCPP, Paul A. Garcia, MD and Brian K. Alldredge, PharmD

School of Pharmacy (Dr. Lee), Loma Linda University, Loma Linda, CA; Schools of Medicine (Drs. Garcia and Alldredge) and Pharmacy (Dr. Alldredge), University of California, San Francisco.

Address correspondence and reprint requests to Dr. Kelly C. Lee, School of Pharmacy, Loma Linda University, 11262 Campus Street, West Hall 1333, Loma Linda, CA 92350; e-mail: kclee{at}rx.llu.edu

The authors reviewed the records of 42 patients with HIV infection and status epilepticus (SE). Brain tumor and infection were the most common etiologies. The median duration of SE was 2.0 ± 10 hours. Most patients (37 [88%]) responded to IV benzodiazepine or phenytoin treatment. Nevertheless, 12 (29%) patients died and 15 (36%) developed new neurologic deficits. In patients with HIV infection, aggressive management of seizures may limit the risk of SE.

Received December 23, 2004. Accepted in final form April 7, 2005.




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