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NEUROLOGY 2005;65:320-322
© 2005 American Academy of Neurology


Brief Communications

The prognosis of hearing impairment complicating HIV-negative cryptococcal meningitis

H. -C. Wang, MD, W. -N. Chang, MD, C. -C. Lui, MD, J. -P. Peng, MD, MSc, C. -R. Huang, MD, H. -W. Chang, PhD, P. -C. Liliang, MD and C. -H. Lu, MD, MSc

From the Departments of Neurosurgery (Dr. Wang), Neurology (Drs. W.-N. Chang, Huang, and Lu), Radiology (Dr. Lui), and Otorhinolaryngology (Dr. Peng), Chang Gung Memorial Hospital, Department of Biology (Dr. H.-W. Chang), National Sun Yat-Sen University, and Department of Neurosurgery (Dr. Liliang), E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.

Address correspondence and reprint requests to Dr. C.-H. Lu, Department of Neurology, Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan; e-mail: chlu99{at}ms44.url.com.tw

Eight patients who had sensorineural hearing loss (SNHL) associated with cryptococcal meningitis were studied. After a minimum 3-year follow-up, one had died. Among the seven survivors, three had improved, two stabilized, and two progressed. Predictive factors included visual disturbance, meningeal enhancements on MRI, and a CSF cryptococcal antigen titer of >1:1,024. SNHL accounted for 30.8% (8/26) of cryptococcal meningitis patients in our study.


Received September 1, 2004. Accepted in final form April 13, 2005.







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