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This Article Figures Only Full Text Full Text (PDF) CME: Take the course for this article: Volume 65, Number 3, August 09, 2005 Polish Data Supplement All Versions of this Article: 01.WNL.0000168259.94991.8av1 65/3/444    most recent Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Berry, J. D. Articles by Petersen, K. L. Search for Related Content PubMed PubMed Citation Articles by Berry, J. D. Articles by Petersen, K. L. Related Collections Viral infections All Clinical trials Clinical trials Randomized controlled (CONSORT agreement) All Pain Neuropathic pain Antiepileptic drugs

A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster

From UCSF Pain Clinical Research Center, Department of Neurology (J.D. Berry and Dr. Petersen), University of California, San Francisco; and Northwestern University Feinberg School of Medicine (J.D. Berry), Chicago, IL.

Address correspondence and reprint requests to Dr. Karin L. Petersen, UCSF Pain Clinical Research Center, 1701 Divisadero St., Suite 480, San Francisco, CA 94115; e-mail: klp{at}itsa.ucsf.edu

This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster. Pain severity decreased by 66% with gabapentin compared to 33% with placebo. Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin.

Editorial, see page 349

This article was previously published in electronic format as an Expedited E-Pub on June 15, 2005, at www.neurology.org.

This study was funded by an investigator-initiated grant from Pfizer, Inc. The study was designed and conducted independently by the authors. Collection, management, analyses, and interpretation of the data were done by the authors in collaboration with Dr. Alan Bostrom, Department of Epidemiology and Biostatistics, UCSF. All data are owned and controlled by the authors. The manuscript was prepared by the authors and was not subject to review or approval by Pfizer. K.L.P. received salary support from NINDS NS39521.

Received January 25, 2005. Accepted in final form March 29, 2005.

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