NEUROLOGY 2005;65:448-450
© 2005 American Academy of Neurology
Brief Communications
The chemokine CXCL13 (BLC): A putative diagnostic marker for neuroborreliosis
T. A. Rupprecht, MD,
H. W. Pfister, MD,
B. Angele,
S. Kastenbauer, MD,
B. Wilske, MD and
U. Koedel, MD
From the Departments of Neurology (Drs. Rupprecht, Pfister, Kastenbauer, Koedel, and B. Angele) and Microbiology (Dr. Wilske), Ludwig-Maximilians University, Munich, Germany.
Address correspondence and reprint requests to Dr. Hans-Walter Pfister, Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, D-81377 Munich, Germany; e-mail: hans-walter.pfister{at}med.uni-muenchen.de
Using protein expression profiling, the authors identified an upregulation of the chemokine B lymphocyte chemoattractant (BLC) in the CSF of patients with neuroborreliosis but not in patients with noninflammatory and various other inflammatory neurologic diseases. This upregulation was confirmed by ELISA, showing increased BLC levels in every neuroborreliosis patient while being undetectable in patients with noninflammatory neurologic diseases. These results point to BLC as a putative additional diagnostic marker for neuroborreliosis.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 9 issue to find the link for this article.
Editorial, see page 351
Disclosure: The authors report no conflicts of interest.
Received July 25, 2004. Accepted in final form April 18, 2005.
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