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Electrical impedance myography in the bedside assessment of inflammatory myopathy

From the Department of Neurology (Drs. Tarulli, Esper, Lee, and Rutkove), Harvard Medical School, Beth Israel Deaconess Medical Center, and Department of Physics (Drs. Aaron and Shiffman), Northeastern University, Boston, MA.

Address correspondence and reprint requests to Dr Rutkove, 330 Brookline Ave, TCC-810, Boston, MA 02446; e-mail: srutkove{at}bidmc.harvard.edu

Electrical impedance myography (EIM) is a new technique with potential for the noninvasive bedside assessment of myopathy. EIM was performed on the quadriceps of 10 patients with inflammatory myopathy and 10 normal subjects. The major EIM parameter, the spatially averaged phase, was 35% lower in the myositis patients and correlated with whole-body (r = 0.765, p = 0.01) and quadriceps (r = 0.673, p = 0.03) strength.

Supported by NIH grant RO1-NS42037-01A2 and grant RR01032 to the Beth Israel Deaconess Medical Center General Clinical Research Center and Harvard Center for Neurodegeneration and Repair grant AY04.

Disclosure: The authors report no conflicts of interest.

Received January 1, 2005. Accepted in final form April 28, 2005.