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NEUROLOGY 2005;65:459-462
© 2005 American Academy of Neurology
Brief Communications

Reduced amplitude of the sural nerve sensory action potential in PARK2 patients

Y. Ohsawa, MD, K. Kurokawa, MD, M. Sonoo, MD, H. Yamada, MD, S. Hemmi, MD, K. Iwatsuki, MD, H. Hagiwara, MD, T. Murakami, MD, T. Shirabe, MD, T. Shimizu, MD and Y. Sunada, MD

From the Division of Neurology, Department of Internal Medicine (Drs. Ohsawa, Kurokawa, Yamada, Hemmi, Iwatsuki, Hagiwara, Murakami, and Sunada), and Department of Neuropathology (Dr. Shirabe), Kawasaki Medical School, Okayama; and Department of Neurology and Neuroscience (Drs. Sonoo and Shimizu), Teikyo University School of Medicine, Tokyo, Japan.

Address correspondence and reprint requests to Dr. Yoshihide Sunada, Division of Neurology, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki-City, Okayama 701-0192, Japan; e-mail: ysunada{at}med.kawasaki-m.ac.jp.

The authors performed nerve conduction studies in nine PARK2 and eight idiopathic Parkinson disease patients and found a significant reduction of sural sensory nerve action potential (SNAP) amplitude in eight PARK2 patients who mostly remained asymptomatic. These data suggest that sensory axonal neuropathy may be a common clinical feature of PARK2 and a reduced amplitude of sural SNAP could be a diagnostic indicator of PARK2.

Supported by the Research Grant (14B-4) for Nervous and Mental Disorders from the Ministry of Health, Labor and Welfare; a Grant (15131301) for Research on Psychiatric and Neurologic Diseases and Mental Health from the Ministry of Health, Labor and Welfare; and JSPS KAKENHI 14370212 and Research Project Grants (No. 15-115B and 16-601) from Kawasaki Medical School.

Disclosure: The authors report no conflicts of interest.

Received November 8, 2004. Accepted in final form April 18, 2005.




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