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Dopaminergic effects on encoding of a motor memory in chronic stroke

From the Human Cortical Physiology Section (Drs. Floel, Hummel, and Cohen), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and Department of Neurology (Drs. Floel, Breitenstein, and Knecht), University of Muenster, Germany.

Address correspondence and reprint requests to Dr Cohen, Human Cortical Physiology Section, NINDS, NIH, Bethesda, MD 20817; e-mail: cohenl{at}ninds.nih.gov

The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relative to placebo. Up-regulation of dopaminergic function may enhance motor memory formation, crucial for successful rehabilitative treatments in patients with chronic stroke.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 9 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received January 10, 2005. Accepted in final form April 13, 2005.

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