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NEUROLOGY 2005;65:475-477
© 2005 American Academy of Neurology


Brief Communications

Marchiafava–Bignami disease: Diffusion-weighted MRI in corpus callosum and cortical lesions

P. Méneégon, MD, PhD, I. Sibon, MD, PhD, C. Pachai, MD, PhD, J. M. Orgogozo, MD, PhD and V. Dousset, MD, PhD

From the Service de Neuroradiologie (Drs. Ménégon and Dousset), Hôpital Pellegrin and Federation of Clinical Neurosciences (Drs. Sibon and Orgogozo), CHU Bordeaux, France; and Theralys Inc. (Dr. Pachai), Lyon, France.

Address correspondence and reprint requests to Dr. Patrice Ménégon, Service de Neuroradiologie, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux, France; e-mail: patrice.menegon{at}chu-bordeaux.fr

The clinical diagnosis of Marchiafava–Bignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.


Disclosure: The authors report no conflicts of interest.

Received July 29, 2004. Accepted in final form April 13, 2005.




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A. V. Khaw, A. Heinrich, P . Menegon, I . Sibon, C . Pachai, J .M. Orgogozo, and V . Dousset
Marchiafava-Bignami disease: Diffusion-weighted MRI in corpus callosum and cortical lesions
Neurology, April 25, 2006; 66(8): 1286 - 1286.
[Full Text] [PDF]

Correspondence:

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Marchiafava–Bignami disease: Diffusion-weighted MRI in corpus callosum and cortical lesions
Alexander V. Khaw, et al.
Neurology Online, 6 Dec 2005 [Full text]
Reply from Authors
Patrice Ménégon, et al.
Neurology Online, 6 Dec 2005 [Full text]



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