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From the Service de Neuroradiologie (Drs. Ménégon and Dousset), Hôpital Pellegrin and Federation of Clinical Neurosciences (Drs. Sibon and Orgogozo), CHU Bordeaux, France; and Theralys Inc. (Dr. Pachai), Lyon, France.
Address correspondence and reprint requests to Dr. Patrice Ménégon, Service de Neuroradiologie, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux, France; e-mail: patrice.menegon{at}chu-bordeaux.fr
The clinical diagnosis of MarchiafavaBignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.
Disclosure: The authors report no conflicts of interest.
Received July 29, 2004. Accepted in final form April 13, 2005.
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A. V. Khaw, A. Heinrich, P . Menegon, I . Sibon, C . Pachai, J .M. Orgogozo, and V . Dousset Marchiafava-Bignami disease: Diffusion-weighted MRI in corpus callosum and cortical lesions Neurology, April 25, 2006; 66(8): 1286 - 1286. [Full Text] [PDF] |
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