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 Volume 65, Number 3, August 09, 2005
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NEUROLOGY 2005;65:481-482
© 2005 American Academy of Neurology
Brief Communications

Delusions and hallucinations in dementia with Lewy bodies: Worsening with memantine

B. H. Ridha, MRCP, K. A. Josephs, MST, MD and M. N. Rossor, MD, FRCP

From the Dementia Research Centre (Drs. Ridha and Rossor), National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (Dr. Josephs), Mayo Clinic and Mayo Foundation, Rochester, MN.

Address correspondence and reprint requests to Dr. Basil Ridha, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, 8-11 Queen Square, London, WC1N 3BG, UK; e-mail: bridha{at}dementia.ion.ucl.ac.uk

Three patients with probable dementia with Lewy bodies (DLB) experienced worsening delusions and visual hallucinations as a result of memantine therapy. Significant resolution occurred once treatment was discontinued. Caution is required when prescribing memantine to patients with possible DLB.

The authors report no conflicts of interest.

Received February 4, 2005. Accepted in final form April 18, 2005.


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