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NEUROLOGY 2005;65:483-485
© 2005 American Academy of Neurology
Brief Communications

Medical decision-making in neurodegenerative disease: Mild AD and PD with cognitive impairment

H. R. Griffith, PhD, M. P. Dymek, PhD, P. Atchison, MD, L. Harrell, MD, PhD and D. C. Marson, JD, PhD

From the Department of Neurology and Alzheimer's Disease Research Center, University of Alabama at Birmingham.

Address correspondence and reprint requests to Dr. Daniel C. Marson, Department of Neurology, JT 1216, University of Alabama at Birmingham, Birmingham, AL 35233-7340; e-mail: dmarson{at}uab.edu

The authors compared medical decision-making capacity in patients with mild Alzheimer disease (AD), Parkinson disease (PD) with cognitive impairment, and older controls. Relative to controls and patients with PD, patients with AD were impaired on the consent ability of understanding the medical treatment situation and choices. Patients with PD were impaired on the consent ability of electing a treatment choice.

Supported in part by an Alzheimer's Disease Center Cores grant (NIH, NIA 1 P30 AG10163-1) (P.I.H., PI), an Alzheimer's Disease Program Project grant (NIH, NIA 5 P01 AG06569-05) (P.I.H., PI), an Alzheimer's Disease Research Center (1P50 AG16582-01) (P.I.H., PI), an Alzheimer's Association Pilot Research Grant (PRG 91-122) (D.C.M., PI), and the Alzheimer's Disease Cooperative Study (Thal, PI), (U01 AGO10483.

Disclosure: The authors report no conflicts of interest.

Received February 16, 2004. Accepted in final form April 25, 2005.


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O. Okonkwo, H. R. Griffith, K. Belue, S. Lanza, E. Y. Zamrini, L. E. Harrell, J. C. Brockington, D. Clark, R. Raman, and D. C. Marson
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