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NEUROLOGY 2005;65:591-592
© 2005 American Academy of Neurology
Brief Communications

Propofol and thiopental for refractory status epilepticus in children

J.P.J. van Gestel, MD, H. J. Blussé van Oud-Alblas, MD, M. Malingré, MD, PhD, F. F.T. Ververs, MD, K. P.J. Braun, MD, PhD and O. van Nieuwenhuizen, MD, PhD

From the Pediatric Intensive Care Unit (Drs. van Gestel and Blussé van Oud-Alblas) and Departments of Pharmacy (Drs. Malingré and Ververs) and Pediatric Neurology (Drs. Braun and van Nieuwenhuizen), University Medical Center Utrecht, Wilhelmina Children’s Hospital, the Netherlands.

Address correspondence and reprint requests to DrJ. van Gestel, Pediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children’s Hospital, PO Box 85090, 3508 AB Utrecht, the Netherlands; e-mail: j.vangestel{at}umcutrecht.nl

To assess safety and efficacy of propofol and thiopental for refractory status epilepticus (RSE) in children, the authors reviewed 34 episodes of RSE. Thiopental was effective in most patients, but there were serious side effects. Propofol was used according to a strict protocol. It was effective in most patients, so that thiopental was not needed. Side effects were infrequent, of minor severity, and fully reversible. The authors suggest the use of propofol before thiopental.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 23 issue to find the title link for this article.

See also page 506.

Disclosure: The authors report no conflicts of interest.

Received September 21, 2004. Accepted in final form April 15, 2005.


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