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NEUROLOGY 2005;65:600-602
© 2005 American Academy of Neurology
Brief Communications

White matter lesion severity in male and female patients with Fabry disease

A. Fellgiebel, MD, M. J. Müller, MD, M. Mazanek, MD, K. Baron, M. Beck, MD and P. Stoeter, MD

From the Department of Psychiatry (Drs. Fellgiebel and Müller), Institute of Neuroradiology (Drs. Mazanek and Stoeter), and Centre for Lysosomal Storage Disorders, Children’s Hospital (Dr. Beck, K. Baron), University of Mainz, Germany.

Address correspondence and reprint requests to Dr. A. Fellgiebel, Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany; e-mail: fellgiebel{at}psychiatrie.klinik.uni-mainz.de

In male patients with Fabry disease (FD), significant age-related cerebral white matter lesions (WMLs) can be found. Although characteristic symptoms including cerebrovascular events are highly prevalent also in females with FD, cerebral structural changes have not been investigated in female FD patients yet. The authors quantified the WML load of 13 male and 14 age-matched female patients with FD and could demonstrate a comparably high frequency and severity of WMLs in both groups.

Editorial, see page 508

Disclosure: The authors report no conflicts of interest.

Received February 10, 2005. Accepted in final form May 16, 2005.


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