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NEUROLOGY 2005;65:612-615
© 2005 American Academy of Neurology
Brief Communications

MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window

P. D. Mitsias, MD, M. Lu, PhD, B. Silver, MD, D. Morris, MD, J. R. Ewing, PhD, S. Daley, RN, C. Lewandowski, MD, A. Katramados, MD, N. I. Papamitsakis, MD, H. B. Ebadian, MS, Q. Zhao, MS, H. Soltanian-Zadeh, PhD, D. Hearshen, PhD, S. C. Patel, MD and M. Chopp, PhD

Departments of Neurology (Drs. Mitsias, Silver, Ewing, Katramados, and Chopp, S. Daley, H.B. Ebadian, and Q. Zhao) Biostatistics and Research Epidemiology (Dr. Lu), Emergency Medicine (Drs. Morris and Lewandowski), and Radiology (Drs. Ewing, Soltanian-Zadeh, Hearshen, and Patel, H.B. Ebadian and Q. Zhao), Henry Ford Health Sciences Center, Detroit, Michigan; New Jersey Neuroscience Institute (Dr. Papamitsakis), JFK Medical Center, Edison, New Jersey; Department of Medical Physics (Dr. Chopp), Oakland University, Rochester, Michigan.

Address correspondence and reprint requests to Dr. Panayiotis D. Mitsias, Department of Neurology, K-11, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202; e-mail: mitsias{at}neuro.hfh.edu

The authors assessed the effect of IV abciximab on early neurologic improvement and ischemic lesion growth in 29 patients with supratentorial stroke and NIH stroke scale score (NIHSSS) ≥ 4 (11.1 ± 5.9), treated within 3 to 24 (13.6 ± 5.5) hours of onset. The 48 to 72-hour NIHSSS improvement was 4.4 ± 3.2 and the 24-hour lesion growth on DWI was +23% (–50%, +103%); 7/26 (27%) patients experienced lesion size decrease. Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth.

Supported by NIH/National Institute of Neurologic Disorders and Stroke grant PO1 NS 23393.

Disclosure: The authors report no conflicts of interest.

Received October 27, 2004. Accepted in final form May 9, 2005.


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