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NEUROLOGY 2005;65:642-644
© 2005 American Academy of Neurology
Brief Communications

Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE {varepsilon}4 carriers

R. O’Hara, PhD, C. M. Schröder, MD, H. C. Kraemer, PhD, N. Kryla, BA, C. Cao, BA, E. Miller, A. F. Schatzberg, MD, J. A. Yesavage, MD and G. M. Murphy, Jr, MD, PhD

From the Department of Psychiatry and Behavioral Sciences (Drs. O’Hara, Schröoder, Kraemer, Schatzberg, and Yesavage, and N. Kryla and C. Cao) and Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences (Dr. Murphy), Stanford University School of Medicine, Stanford University, CA; Harvard University (E. Miller), Boston, MA; and VA Palo Alto Health Care System (Drs. Yesavage and Murphy), CA.

Address correspondence and reprint requests to Dr. Ruth O’Hara, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550; e-mail: roh{at}leland.stanford.edu

The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE {varepsilon}4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in {varepsilon}4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE {varepsilon}4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the August 23 issue to find the title link for this article.

Supported in part by the Medical Research Service of the VA Palo Alto Health Care System; by National Institutes of Health grants AG 18784 and AG 17824; and by the Department of Veteran Affairs Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC).

Disclosure: The authors report no conflicts of interest.

Received December 1, 2004. Accepted in final form May 5, 2005.




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