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NEUROLOGY 2005;65:645-647
© 2005 American Academy of Neurology
Brief Communications

Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

K. A. Josephs, MST, MD, D. S. Knopman, MD, J. L. Whitwell, BA, B. F. Boeve, MD, J. E. Parisi, MD, R. C. Petersen, MD, PhD and D. W. Dickson, MD

From the Departments of Neurology (Drs. Josephs, Knopman, Boeve, and Petersen), Radiology Research (J.L. Whitwell), and Laboratory Medicine and Pathology (Dr. Parisi), Mayo Clinic, Rochester, MN; and Department of Pathology and Neuroscience (Dr. Dickson), Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Dr. Keith A. Josephs, Department of Neurology, Mayo Clinic, 200 First St S.W., Rochester, MN 55905; e-mail: josephs.keith{at}mayo.edu

Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

Supported by grants P50 AG16574 and U01 AG06786 from the National Institute on Aging, Bethesda, MD; and by the Robert H. and Clarice Smith and Abigail Van Buren AD Research Programs of the Mayo Foundation.

Disclosure: The authors report no conflicts of interest.

Received March 9, 2005. Accepted in final form May 3, 2005.




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