NEUROLOGY 2005;65:745-747
© 2005 American Academy of Neurology
Brief Communications
Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
H. D. Rosas, MD,
N. D. Hevelone, MPH,
A. K. Zaleta, BA,
D. N. Greve, PhD,
D. H. Salat, PhD and
B. Fischl, PhD
From the Department of Neurology (Dr. Rosas), Center for Neuroimaging of Aging and Neurodegenerative Diseases (Drs. Rosas and Salat, N.D. Hevelone, and A.K. Zaleta), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Athinoula A. Martinos Center for Biomedical Imaging (Drs. Rosas, Salat, and Fischl, N.D. Hevelone, and A.K. Zaleta), Massachusetts General Hospital/Harvard Medical School, Charlestown, MA.
Address correspondence and reprint requests to Dr. H. Diana Rosas, Center for Neuroimaging of Aging and Neurodegenerative Diseases, 149 13th Street, Room 2273, Charlestown, MA 02129; e-mail: rosas{at}helix.mgh.harvard.edu
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
Support for this research was provided in part by the NIH, National Institute of Neurologic Disorders and Stroke NS042861, the National Center for Research Resources (P41-RR14075, R01 RR16594-01A1, and the NCRR BIRN Morphometric Project BIRN002) as well as the Rappaport Scholars Fund, the Claflin Scholars fund and the Mental Illness and Neuroscience Discovery (MIND) Institute.
Disclosure: The authors report no conflicts of interest.
Received October 19, 2004. Accepted in final form May 23, 2005.
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|
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|
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|
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|
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|
|
|
|
|
|
|
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|
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