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 Volume 65, Number 5, September 13, 2005
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NEUROLOGY 2005;65:762-764
© 2005 American Academy of Neurology
Brief Communications

Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

A. Crespel, MD, PhD, P. Genton, MD, M. Berramdane, MD, P. Coubes, MD, PhD, C. Monicard, PharmD, M. Baldy-Moulinier, MD and P. Gelisse, MD

From the Epilepsy Unit (Drs. Crespel, Berramdane, Coubes, Monicard, Baldy-Moulinier, and Gelisse), Hôpital Gui de Chauliac, Montpellier; and Centre Saint Paul-H. Gastaut (Dr. Genton), Marseille, France.

Address correspondence and reprint requests to Dr. Arielle Crespel, Explorations Neurologiques et Epileptologie, Hôpital Gui de Chauliac, 80 avenue Fliche, 34295 Montpellier cedex 05, France; e-mail: a-crespel{at}chu-montpellier.fr

Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.

Received January 27, 2005. Accepted in final form May 16, 2005.

Disclosure: The authors report no conflicts of interest.




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