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Lack of ß-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC

From the Department of Pathology, University of Washington, Seattle.

Address correspondence and reprint requests to Dr Montine, Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104; e-mail: tmontine{at}u.washington.edu

High levels of ß-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson–dementia complex. In contrast to others, they detected no free BMAA in any of these samples.

Supported by the Nancy and Buster Alvord Endowment and grants from NIH (AG05136 and AG14382).

Disclosure: The authors report no conflicts of interest.

Received April 19, 2005. Accepted in final form May 6, 2005.

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