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Published online before print July 28, 2005, doi:10.1212/01.wnl.0000173835.12308.bb)
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NEUROLOGY 2005;65:919-921
© 2005 American Academy of Neurology
Brief Communications

Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

M. Diomedi, MD, F. Sallustio, MD, B. Rizzato, MD, F. Ferrante, MD, G. Leone, MD, E. Spera, MD, M. Scarfini, MD and G. Bernardi, MD

From the Fondazione Santa Lucia IRCCS, Rome (Drs. Diomedi and Bernardi), and the Neurological Clinic (Drs. Diomedi, Sallustio, Rizzato, Ferrante, Leone, and Bernardi) and Department of Urology (Drs. Spera and Scarfini), Tor Vergata University, Rome, Italy.

Address correspondence and reprint requests to Dr. M. Diomedi, Clinica Neurologica, Policlinico Tor Vergata, Viale Oxford, 81, 00133 Rome, Italy; e-mail: marina.diomedi{at}uniroma2.it

The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

See Commentary, page 785

This article was previously published in electronic format as an Expedited E-Pub on July 28, 2005, at www.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received March 21, 2005. Accepted in final form June 3, 2005.




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