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NEUROLOGY 2005;65:928-930
© 2005 American Academy of Neurology
Brief Communications

Increasing incidence of late-onset anti–AChR antibody–seropositive myasthenia gravis

Finn E. Somnier, MD, DSc (Med)

From the Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark.

Address correspondence and reprint requests to Dr Somnier, Department of Autoimmunology, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark; e-mail: Somnier{at}dadlnet.dk

The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10-6. In late-onset MG, the rate increased from 4.7 to 20.8 x 10-6. The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti–acetylcholine receptor antibody–seropositive MG may be provoked by environmental factors.

Supported by Civil Engineer Walter Christensen and O. Kristiane Christensen’s Fund, a private nonprofit foundation devoted to promoting myasthenia gravis research.

Disclosure: The author reports no conflicts of interest.

Received March 8, 2005. Accepted in final form June 8, 2005.




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N. Tsinzerling, A.-K. Lefvert, G. Matell, and R. Pirskanen-Matell
Myasthenia gravis: a long term follow-up study of Swedish patients with specific reference to thymic histology
J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1109 - 1112.
[Abstract] [Full Text] [PDF]


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