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From the Department of Neurology, St Vincent’s University Hospital and University College (Drs. O’Dwyer, O’Riordan, Molloy, and Hutchinson); the Department of Neurology, Mater Misericordiae University Hospital (Dr. Lynch), Dublin, Ireland; and the Department of Neurology (Drs. Saunders-Pullman and Bressman), Beth Israel Medical Center and Albert Einstein College of Medicine, New York, New York.
Address correspondence and reprint requests to Dr. M. Hutchinson, Newman Clinical Research Professor, Department of Neurology, St Vincent’s University Hospital, Elm park, Dublin 4, Ireland; e-mail: mhutchin{at}iol.ie
Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.
Editorial, see page 792
Disclosure: The authors report no conflicts of interest.
Presented in part at the 57th Annual Meeting of the American Academy of Neurology, Miami, April 9–16, 2005.
Received February 10, 2005. Accepted in final form May 24, 2005.
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