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NEUROLOGY 2005;65:947-949
© 2005 American Academy of Neurology
Brief Communications

Asynchronous burst-suppression in a child with callosal Ki-1 anaplastic large cell lymphoma

J. Hukin, MBBS, FRCPC, A. Davey, FRCPC, MD, P. Wong, BEng, MD, FRCPC, G. Hendson, MBBCH, FRCPC, C. Aquino-Parsons, MD, FRCP, J. Wu, MBBS, MSC, FRCPC and M. Sargent, MD, FRCPC

From the Division of Neurology (Dr. Hukin), Department of EEG/EMG (Dr. Wong), Department of Anatomic Pathology (Dr. Hendson), Division of Oncology (Dr. Wu), and Division of Radiology (Dr. Sargent), British Columbia’s Children’s Hospital, University of British Columbia; Department of Pediatrics (Dr. Davey), Inland Hospital, Kamloops; and Radiation Oncology (Dr. Aquino-Parsons), British Columbia’s Cancer Agency, Canada.

Address correspondence and reprint requests to Dr. Juliette Hukin, Clinical Assistant Professor, Division of Neurology & Oncology, Children’s and Women’s Hospital, University of British Columbia, Children’s Ambulatory Care Bldg., 4480 Oak Street, Rm: K3-147, Vancouver, BC V6H 3V4, Canada; e-mail: jhukin{at}cw.bc.ca

A 13-year-old girl with Ki-1 anaplastic large cell lymphoma (Ki-1ALCL) bulky deposits in the brain developed raised intracranial pressure and coma associated with asynchronous burst-suppression following standard dose cranial irradiation. Supportive care, steroids, and chemotherapy resulted in clinical improvement. Burst-suppression coma may be reversible when secondary to tumor, decrease in steroids, or radiation effects; the asynchrony localizes the lesion to cortical interconnections such as the corpus callosum.

Disclosure: The authors report no conflicts of interest.

Received July 7, 2004. Accepted in final form May 16, 2005.






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