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NEUROLOGY 2005;65:953-955
© 2005 American Academy of Neurology
Brief Communications

Education modifies the association of amyloid but not tangles with cognitive function

D. A. Bennett, MD, J. A. Schneider, MD, R. S. Wilson, PhD, J. L. Bienias, ScD and S. E. Arnold, MD

From the Rush Alzheimer's Disease Center and Department of Neurological Sciences (Drs. Bennett, Schneider, and Wilson) and Rush Institute for Healthy Aging and Department of Internal Medicine (Dr. Bienias), Rush University Medical Center, Chicago, IL, and Center for Neurobiology and Behavior (Dr. Arnold), University of Pennsylvania, Philadelphia.

Address correspondence and reprint requests to Dr Bennett, Rush Alzheimer's Disease Center; 600 S. Paulina, Suite 1028, Chicago, IL 60612; e-mail: dbennett{at}rush.edu

The authors quantified amyloid and tau tangles in Religious Orders Study participants. In separate analyses, amyloid and tangles were related to level of cognition. When terms for education's interaction with amyloid and tangles were added, education dampened the association of amyloid with level of cognition (p = 0.02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition.

Supported by National Institute on Aging grants R01 AG15819, P30 AG10161, and R01 AG17917.

Disclosure: The authors report no conflicts of interest.

Received February 18, 2005. Accepted in final form May 16, 2005.




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