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Moyamoya disease in Washington State and California

From the Department of Neurology (Dr. Uchino), University of Pittsburgh, Pittsburgh, PA; Departments of Neurology and Epidemiology (Dr. Johnston), University of California, San Francisco, CA; Department of Neurology (Drs. Becker and Tirschwell), Harborview Medical Center and University of Washington School of Medicine, Seattle, WA.

Address correspondence and reprint requests to Dr. Ken Uchino, UPMC Stroke Institute, 200 Lothrop Street, PUH C-400, Pittsburgh, PA 15213; e-mail: uchinok{at}upmc.edu

The authors identified 298 diagnoses of moyamoya in California and Washington from hospital discharge databases during the period 1987 to 1998. The incidence was 0.086/100,000 persons. The ethnicity-specific incidence rate ratios compared to whites were 4.6 (95% CI: 3.4 to 6.3) for Asian Americans, 2.2 (95% CI: 1.3 to 2.4) for African Americans, and 0.5 (95% CI: 0.3 to 0.8) for Hispanics. The incidence of moyamoya in Washington and California was lower than reported in Japan, but the rate among U.S. Asians is similar.

Supported by NIH/National Institute of Neurologic Disorders and Stroke grants K02NS02254 (S.C.J.), K02NS02160 (K.J.B.), and K23NS02119 (D.L.T.).

Disclosure: The authors report no conflicts of interest.

Received August 1, 2004. Accepted in final form May 25, 2005.

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