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NEUROLOGY 2005;65:959-961
© 2005 American Academy of Neurology
Brief Communications

Clinical outcome in patients with high-grade internal carotid artery stenosis after irradiation

M. Marcel, MD, D. Leys, MD, PhD, F. Mounier-Vehier, MD, D. Bertheloot, MD, E. Lartigau, MD, PhD, J. P. Pruvo, MD, PhD, M. Al-Koussa, MD, D. Chevalier, MD, PhD and H. Henon, MD, PhD

From the Departments of Neurology (Drs. Marcel, Leys, and Henon), Neuroradiology (Dr. Pruvo), Vascular Surgery (Dr. Al-Koussa), and Laryngology (Dr. Chevalier), Lille University Hospital, Lille, France; Department of Radiotherapy (Dr. Lartigau), Centre Oscar Lambret, Lille, France; Department of Neurology (Drs. Marcel and Mounier-Vehier) and Radiology (Dr. Bertheloot), Lens Hospital, Lens, France.

Address correspondence and reprint requests to Prof. D. Leys, Department of Neurology, Stroke Department, University of Lille, Roger Salengro Hospital, F-59037 Lille, France; e-mail: dleys{at}chru-lille.fr

The authors followed up 41 consecutive patients (21 symptomatic) with internal carotid artery stenosis ≥70% and previous neck irradiation. After 28 months, 15 patients (36.6%) had died, five (12.2%) had had an ischemic stroke, and 15 (36.6%) had a new malignancy. Having a new malignancy was the only independent predictor of death. The major risk for patients with ICA stenosis ≥70% and previous neck irradiation is malignancy, not stroke.

Funded by grant EA 2691 from the French Ministry of Education, Research and Technology.

Disclosure: The authors report no conflicts of interest.

Received January 29, 2005. Accepted in final form June 6, 2005.