HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hadjigeorgiou, G. M. Articles by Karantanas, A. Search for Related Content PubMed PubMed Citation Articles by Hadjigeorgiou, G. M. Articles by Karantanas, A. Related Collections All Cerebrovascular disease/Stroke Brain trauma Intracerebral hemorrhage Association studies in genetics

IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury

From the Neurogenetics Unit, Department of Neurology (Drs. Hadjigeorgiou, Dardiotis, Aggelakis, Xiromerisiou, and Papadimitriou, M. Dardioti), and Department of Neurosurgery (Drs. Paterakis and Tasiou), University Hospital of Larissa, Medical School, University of Thessaly, ICU (Dr. Komnos) and CT and MRI Unit (Dr. Karantanas), General Hospital of Larissa, and Department of Biomathematics (Dr. Zintzaras), Medical School, University of Thessaly, Larissa, Greece; and Department of Neurology and Taub Institute (Dr. Scarmeas), Columbia University Medical Center, New York, NY.

Address correspondence and reprint requests to Dr Hadjigeorgiou, Neurogenetics Unit, Department of Neurology, Medical School, University of Thessaly, Papakyriazi 22 St., Larissa 41222, Greece; e-mail: gmhadji{at}med.uth.gr

Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI).

Methods: Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant.

Results: Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI (adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant.

Conclusion: There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.

Disclosure: The authors report no conflicts of interest.

Received February 18, 2005. Accepted in final form June 25, 2005.

This article has been cited by other articles:

				M. Wilson and H. Montgomery Impact of genetic factors on outcome from brain injury Br. J. Anaesth., July 1, 2007; 99(1): 43 - 48. [Abstract] [Full Text] [PDF]

				B. B. Worrall, T. G. Brott, R. D. Brown Jr, W. M. Brown, S. S. Rich, S. Arepalli, F. Wavrant-De Vrieze, J. Duckworth, A. B. Singleton, J. Hardy, et al. IL1RN VNTR Polymorphism in Ischemic Stroke: Analysis in 3 Populations Stroke, April 1, 2007; 38(4): 1189 - 1196. [Abstract] [Full Text] [PDF]