Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print July 20, 2005, doi:10.1212/01.wnl.0000171957.90640.b5)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
01.wnl.0000171957.90640.b5v1
65/7/1101    most recent
Right arrow Correspondence:
Submit a response
Right arrow Correspondence:
View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in Neurology
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frank, S.
Right arrow Articles by Kim, S. Y.H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frank, S.
Right arrow Articles by Kim, S. Y.H.
Related Collections
Right arrow Parkinson's disease/Parkinsonism
Right arrow All Clinical trials
NEUROLOGY 2005;65:1101-1103
© 2005 American Academy of Neurology
Brief Communications

What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports

Samuel Frank, MD, Karl Kieburtz, MD, MPH, Robert Holloway, MD, MPH and Scott Y.H. Kim, MD, PhD

From Boston University (Dr. Frank), MA; University of Michigan (Dr. Kim), Ann Arbor; and University of Rochester (Drs. Kieburtz and Holloway), NY.

Address correspondence and reprint requests to Dr. Samuel Frank, 715 Albany Street, C329, Boston, MA 02118; e-mail: samfrank{at}bu.edu

Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.

Editorial, see page 982.

This article was previously published in electronic format as an Expedited E-Pub on July 20, 2005, at www.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received February 2, 2005. Accepted in final form May 16, 2005.


Related articles in Neurology:

October 11 Highlights

Neurology 2005 65: 976-977. [Full Text]  

Assessing the risk of a necessary harm: Placebo surgery in Parkinson disease
Olivier Rascol
Neurology 2005 65: 982-983. [Full Text]  



This article has been cited by other articles:


Home page
 NeurologyHome page
W. Landau, S. A. Frank, K. Kieburtz, R. Holloway, and S. Y.H. Kim
What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports
Neurology, June 13, 2006; 66(11): 1788 - 1789.
[Full Text] [PDF]

Home page
 NeurologyHome page
O. Rascol
Assessing the risk of a necessary harm: Placebo surgery in Parkinson disease
Neurology, October 11, 2005; 65(7): 982 - 983.
[Full Text] [PDF]

Correspondence:

Read all Correspondence

What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports
William Landau
Neurology Online, 8 Mar 2006 [Full text]
Reply from the authors
Samuel A. Frank, et al.
Neurology Online, 8 Mar 2006 [Full text]

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.