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CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

From the Department of Neurology (Drs. Reijneveld, Brandsma, and Taphoorn), Laboratory of Medical Oncology from the Division of Medical Oncology (Drs. Reijneveld, Brandsma, and Voest), and the Julius Center for General Practice and Patient Oriented Research (Dr. Kalmijn), University Medical Center Utrecht; Department of Chemical Endocrinology (Dr. Geurts-Moespot), University Medical Center "St. Radboud," Nijmegen; Departments of Neurology (Dr. Boogerd) and Clinical Chemistry (Dr. Bonfrer), Antoni van Leeuwenhoekhuis, Amsterdam; Department of Neurology (Dr. Taphoorn), Medical Center "Haaglanden," Den Haag; and Department of Neurology (Drs. Reijneveld and Visser), VU University Medical Center, Amsterdam, The Netherlands.

Address correspondence and reprint requests to Dr Reijneveld, Department of Neurology, HP-2A.87, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands; e-mail: jc.reijneveld{at}vumc.nl

The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.

Disclosure: The authors report no conflicts of interest.

Received April 27, 2005. Accepted in final form June 10, 2005.

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				B. van de Langerijt, J. M. Gijtenbeek, H.P.M. de Reus, F. C.G.J. Sweep, A. Geurts-Moespot, J. C.M. Hendriks, A. C. Kappelle, and M. M. Verbeek CSF levels of growth factors and plasminogen activators in leptomeningeal metastases. Neurology, July 11, 2006; 67(1): 114 - 119. [Abstract] [Full Text] [PDF]

				M. D. Groves, J. C. Reijneveld, and D. Brandsma CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases Neurology, May 23, 2006; 66(10): 1609 - 1610. [Full Text] [PDF]

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