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From the Neuroimaging Research Unit (Drs. Valsasina, Benedetti, Rovaris, and Filippi), Department of Neurology (Drs. Benedetti, Rovaris, Comi, and Filippi), Scientific Institute and University H San Raffaele, Milan; and Unit of Clinical Epidemiology (Dr. Sormani), National Cancer Institute, Genoa, Italy.
Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132 Milan, Italy; e-mail: filippi.massimo{at}hsr.it.
Little is known about the temporal evolution of gray matter damage occurring early in the course of multiple sclerosis (MS). The authors investigated the evolution of gray matter volume loss in 117 patients with relapsing–remitting MS, scanned monthly for a 9-month period. Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing–remitting MS evolves markedly over a short period of observation.
Disclosure: M. Filippi, MD, G. Comi, MD, M. Rovaris, MD, and M.P. Sormani, PhD, received honoraria—M. Filippi and G. Comi's honoraria exceeded $10,000—from TEVA for their participation in the MRI-monitored European/Canadian glatiramer acetate trial. This study is based on the placebo data of the above-mentioned trial but was conducted independently and without any sponsorship.
Received April 1, 2005. Accepted in final form June 16, 2005.
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