| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Mayo Alzheimer Disease Research Center and the Departments of Neurology (Drs. Knopman, Petersen, and Rocca) and Health Sciences Research (R.H. Cha and Drs. Edland and Rocca), Mayo Clinic College of Medicine, Rochester, MN.
Address correspondence and reprint requests to Dr Knopman, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail: knopman{at}mayo.edu
Objective: To study coronary artery bypass grafting (CABG) as a risk factor for dementia and Alzheimer disease (AD) using a case-control design.
Methods: The authors used the records-linkage system of the Rochester Epidemiology Project to ascertain incident cases of dementia in Rochester, MN, for the 5-year period 1990 to 1994. The authors defined dementia and AD using the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Each case was individually matched by age (±1 year) and sex to a person drawn randomly from the same population, and free of dementia in the index year (year of onset of dementia in the matched case).
Results: Among 557 dementia cases, 24 (4.3%) had undergone a CABG prior to the onset of dementia with a median lag time of 5.5 years (range = 0.1 to 15.9). Among 557 controls, 28 subjects (5.0%) had undergone a CABG prior to the index year with a median lag time 3.9 years (range = 0.1 to 12.3); OR = 0.85 (95% CI = 0.49 to 1.49; p = 0.57) for dementia and OR = 0.78 (95% CI = 0.39 to 1.56; p = 0.48) for AD. The findings did not change after adjustment for education. The perioperative courses of cases and controls were comparable. Analyses including only the 481 cases of dementia with presumed neurodegenerative or cerebrovascular etiology were also negative.
Conclusions: This population-based case-control study suggests that coronary artery bypass grafting is not a major risk factor for dementia overall, or for Alzheimer disease.
Editorial, see page 978
See also page 991
This article was previously published in electronic format as an Expedited E-Pub on July 6, 2005, at www.neurology.org.
Supported by grants U01 AG06786 (Mayo Alzheimer’s Disease Patient Registry) and P50 AG16574 (Mayo Alzheimer’s Disease Research Center) from the National Institute on Aging, and made possible by the Rochester Epidemiology Project grant R01 AR30582, and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program of the Mayo Foundation.
The authors report no conflicts of interest.
Received January 27, 2005. Accepted in final form May 16, 2005.
This article has been cited by other articles:
|
|
 |
|
  D. Baranov, P. E. Bickler, G. J. Crosby, D. J. Culley, M. F. Eckenhoff, R. G. Eckenhoff, K. J. Hogan, V. Jevtovic-Todorovic, A. Palotas, M. Perouansky, et al. Consensus Statement: First International Workshop on Anesthetics and Alzheimer's Disease Anesth. Analg., May 1, 2009; 108(5): 1627 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. I. Khalpey, R. B. Ganim, and J. D. Rawn Postoperative Care of Cardiac Surgery Patients Card. Surg. Adult, January 1, 2008; 3(2008): 465 - 486. [Full Text]
|
|
|
|
 |
|
 D. S. Knopman, S. D. Edland, R. H. Cha, R. C. Petersen, and W. A. Rocca Incident dementia in women is preceded by weight loss by at least a decade Neurology, August 21, 2007; 69(8): 739 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Grocott Genetic influences on cerebral outcome after cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 291 - 296. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Samuels Can Cognition Survive Heart Surgery? Circulation, June 20, 2006; 113(24): 2784 - 2786. [Full Text] [PDF]
|
|
|
|
|
|
M. M. Bednar, T. A. Lee, B. Wolozin, K. B. Weiss, D. S. Knopman, and W. A. Rocca Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease Neurology, June 13, 2006; 66(11): 1785 - 1785. [Full Text] [PDF]
|
|
|
|
 |
|
 Cognitive Decline and Dementia After CABG Journal Watch Psychiatry, May 17, 2006; 2006(517): 8 - 8. [Full Text]
|
|
|
|
 |
|
 Cognitive Decline and Dementia After CABG Journal Watch Neurology, March 23, 2006; 2006(323): 6 - 6. [Full Text]
|
|
|
|
 |
|
 F. Bursi, W. A. Rocca, J. M. Killian, S. A. Weston, D. S. Knopman, S. J. Jacobsen, and V. L. Roger Heart Disease and Dementia: A Population-based Study Am. J. Epidemiol., January 15, 2006; 163(2): 135 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Minerva BMJ, October 29, 2005; 331(7523): 1032 - 1032. [Full Text] [PDF]
|
|
|
|
|
|
W. S. Smith and M. Mapstone Does extracorporeal circulation harm the brain? Neurology, October 11, 2005; 65(7): 978 - 979. [Full Text] [PDF]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
